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KMID : 0617219980090010089
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Duksung Bulletin Phamaceutical Sciences
1998 Volume.9 No. 1 p.89 ~ p.93
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Dissolution of Crystal Forms of Cefortaxime Sodium
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Abstract
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Three polymorphic modifications and two pseudopolymorphic modifications of cefotaxime sodium were obtained by crystallization from different organic solvents. The isolated crystal forms were characterized by UV spectrophotometry. DSC, TGA and X-ray crystallography. Crystal forms of cefotaxime sodium were also compared by dissolution rate. The dissolution rate of form 1 was the highest, followed by form 2, form 4, form 6, form5 and form 3. Among these polymorphic modifications the dissolution rate of form 3 and form 5 was much slower than that of cefotaxime sodium on the market. All forms showed no change after 2-month storage test in the silica gel desiccator. But after the storage of 2-month at 95％ relative humidity condition, all forms were deliquesced by hygroscopic property except form 1 that showed the highest dissolution rate. At 52％ relative humidity condition, form 1, form2 and form 6 had no evidence of phase transformation, but form 3, form 4 and form 5 were also deliquesced.
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